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ORIGINAL ARTICLE
Year : 2013  |  Volume : 4  |  Issue : 3  |  Page : 120-128

The effect of hydrophilic and hydrophobic polymers on release profiles of diclofenac sodium from matrix tablets


1 Department of Pharmacy, Laboratory of Natural Products Research, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; College of Pharmacy, Chosun University, 375 Seosuk dong, Gwangju 501 759, Republic of Korea
2 Department of Pharmacy, Laboratory of Natural Products Research, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; School of Biomedical Science, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
3 Department of Pharmacy, Laboratory of Natural Products Research, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; College of Pharmacy, Chosun University, 375 Seosuk dong, Gwangju 501 759, Republic of Korea; School of Pharmacy, University of Waterloo, Waterloo, ON, N2G 2B2 Canada
4 College of Pharmacy, Chosun University, 375 Seosuk dong, Gwangju 501 759, Republic of Korea
5 Department of Pharmacy, Laboratory of Natural Products Research, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
6 School of Continuing Studies, University of Toronto, Toronto, ON, M5S 2V8 Canada

Correspondence Address:
Tanveer A Khan
Health Sciences Division, Exova Canada Inc., Mississauga, ON, L5K 1B3 Canada

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Source of Support: Authors are declaring no conflict of interest. There is no conflict of interest between the authors., Conflict of Interest: None


DOI: 10.4103/2045-080X.119064

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Objective: The current study aimed to develop a matrix type sustained release Diclofenac tablet, using hydrophilic hydroxypropyl methylcellulose (HPMC) and hydrophobic polymer cetyl alcohol (CA). Materials and Methods: Two different polymers, that is, Methocel K15MCR® and CA were used in various proportions as release controlling factor. Matrix tablets were prepared by wet granulation technique. The physicochemical properties of the granules and tablets were evaluated. In vitro dissolution studies of prepared matrix tablet and patent product Voltaren SR® tablet (VSR) were performed at pH 7.4 phosphate buffer at 100 rpm, and at 37 ± 0.5°C, and subjected to in vitro bioequivalence study in terms of similarity and difference factors. Stability studies were conducted for 6 months using optimized formulation for extended period of time, both at room temperature and accelerated conditions. The dissolution data were fit to Zero-order, First-order, Higuchi, and Korsmeyer-Peppas' equations. Results: The formulated tablets showed acceptable weight variation, hardness, drug content uniformity with sustained release matrix characteristics. Hydrophilic Methocel K15 MCR® matrices-based tablets showed zero-order and hydrophobic CA matrices-based tablets followed first-order kinetics except for formulation six (F6 showed zero-order profile). It was found that formulations containing CA showed better dissolution properties with respect to formulations containing Methocel K15 MCR® in terms of similarity and difference factor. Furthermore, the formulations F4, F5, and F6 exhibited similar drug release profile as compared with VSR tablet, which indicated that these formulations could be bioequivalent with VSR tablet in vitro. Tablets were stable both at room temperature and as well as at accelerated conditions. Conclusion: The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCR® and CA in the form of matrix tablets with similar dissolution profile of patent product Voltaren SR® . The type of polymers used was found to induce a profound effect on release rate and mechanism.


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