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ORIGINAL ARTICLE
Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 14-17

Knowledge of warfarin therapy among patients attending Warfarin Clinic at a Public Hospital in Northern part of Malaysian Peninsular


1 Department of Pharmacy, Hospital Pulau Pinang, Pulau Pinang, Malaysia
2 Department of Clinical Pharmacy, Universiti Sains Malaysia, Penang, Malaysia
3 Department of Pharmaceutical Practice, Princess Nora University, Riyadh, Saudi Arabia
4 Department of Clinical Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarrah, Saudi Arabia

Date of Web Publication27-Jan-2016

Correspondence Address:
Syed Azhar Syed Sulaiman
Department of Clinical Pharmacy, Universiti Sains Malaysia, Penang
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2045-080X.174931

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  Abstract 

Background: Patient's knowledge of anticoagulation therapy is important to achieving and maintaining optimal therapy outcome as well as reducing adverse events. The aim of this study was to assess knowledge of warfarin therapy among patients attending Warfarin Clinic at a public hospital.
Materials and Method: A cross-sectional survey of 128 patients was conducted at a Warfarin Clinic. Face to face interviews were conducted, using standard questionnaires to determine demographic characteristics and knowledge of warfarin therapy.
Results: The mean age of participants was 50.5 years. Majority of patients were male (56.2%), Malays (46.89%) and married (78.1%). A large proportion of patients had only primary (33.6%) and secondary school education (43.0%). The result indicates almost all patients know the indication (95.8%) and dosage (92.2%) of warfarin. In addition, 89.1% of patients know what to do in case of a missed dose. However, more than half of participants do not know the consequence of missing a dose. Most patients know the purpose of INR monitoring and the consequence of INR value above or below the therapeutic range. There were only 42.2% of the patients who know the frequency of INR monitoring. Knowledge of drug interaction indicates more than 50% of patients possess knowledge of warfarin-alcohol, warfarin-vitamin, warfarin-OTC and warfarin-food interaction. There were 64.1% of patients who know when to seek immediate medical attention and 56.3% who are aware of side effect monitoring. Categorization of knowledge level shows 41.4% of patients have good level of knowledge about anticoagulation therapy. However, only 33.6% of patients have excellent knowledge while 1.6% of patients were found to have poor knowledge of warfarin therapy.
Conclusion: It can be concluded majority of patients attending warfarin clinic have insufficient knowledge about warfarin therapy.

Keywords: Anticoagulation therapy, international normalized ratio, knowledge, warfarin


How to cite this article:
Ching TB, Sulaiman SS, Suleiman AK, Gillani SW, Abubakar U. Knowledge of warfarin therapy among patients attending Warfarin Clinic at a Public Hospital in Northern part of Malaysian Peninsular. Arch Pharma Pract 2016;7:14-7

How to cite this URL:
Ching TB, Sulaiman SS, Suleiman AK, Gillani SW, Abubakar U. Knowledge of warfarin therapy among patients attending Warfarin Clinic at a Public Hospital in Northern part of Malaysian Peninsular. Arch Pharma Pract [serial online] 2016 [cited 2019 Aug 19];7:14-7. Available from: http://www.archivepp.com/text.asp?2016/7/1/14/174931


  Introduction Top


Warfarin therapy is increasingly used for the prevention and treatment of various thrombotic diseases. [1],[2] Warfarin has been the mainstay oral anticoagulant for the several decades despite its narrow therapeutic index and difficulties to use. [3] The safety and effectiveness of warfarin depend critically on maintaining international normalized ratio (INR) within therapeutic range. [4] Suboptimal anticoagulation control is a significant problem because it may lead to hemorrhagic and thromboembolic events. [5]

Poor patient knowledge about warfarin therapy has been found to be associated with worse anticoagulation control [1],[6],[7] and increased frequency of hemorrhagic events. [7],[8] Achieving optimal outcomes with oral anticoagulants requires regular monitoring of the prothrombin time, expressed as the INR, and related dosage changes are necessary. [6] In addition, good knowledge and understanding improve compliance to warfarin therapy. [1],[2] The aim of this study was to assess knowledge of warfarin therapy among patients attending Warfarin Clinic.


  Methodology Top


Study design and location

This cross-sectional study was conducted over 4 months at Warfarin Clinic, Penang Hospital. The clinic was established in 2008 to review and manage patients on warfarin from cardiothoracic and cardiology clinic, and in 2009, the scope was expanded to outpatient department.

Sample size determination

The required sample size was calculated to be 122 using a significance level of 0.05 and 80% power. [9]

Inclusion criteria

All adult patients who had attended Warfarin Clinic at least 8 times were included. A minimum of eight visits was chosen to ensure patients have enough exposure to the clinic.

Exclusion criteria

Patients below 18 years who have mental illness or dementia or cannot communicate in Malay, Chinese, or English language were excluded.

Data collection

A standardized form was used to obtain patient demographic information such as age, gender, race, educational level, marital status, and indication for warfarin therapy.

A validated questionnaire was adapted and used to assess participant's knowledge of warfarin therapy. This questionnaire was developed by Zeolla et al. and had been tested for validity and reliability. [10] The questionnaire consists of five domains that are basic drug information, side effects, drug interaction, INR monitoring, and missed dose. An assessment tool consisting of four responses for every question was chosen which has one correct answer and three distractors. The questionnaire was used after approval was given by the author.

The adapted questionnaire was translated into Malay and Chinese languages using the forward-backward translation method to ensure conceptual equivalence. The translated questionnaire was validated by a panel of two physicians and two senior pharmacists at the study hospital.

A face to face interview was conducted at the clinic using the validated questionnaire to assess patient's knowledge of warfarin therapy.

Data analysis

Data entry and statistical analysis were performed using  Statistical Package for Social Science version 17. Results were presented in frequencies and percentages. For the purpose of analysis, each correct answer was assigned a point, and the total point obtained was transformed into percentage to indicate the patients' overall knowledge on warfarin therapy. Knowledge score were categorized as follows: Patients who provide 0-5, 6-10, 11-15, and 16-20 correct answers were categorized as having poor, fair, good, and excellent knowledge respectively.

Ethical consideration

The study was approved by Medical Research Ethics Committee, Malaysia. The registration number of the study is Nmrr-09-642-4405.


  Results Top


A total of 128 patients participated in the study. The mean age (standard deviation) of the participants was 50.53 (14.32) years old to The mean age of the participants was 50.5 years. Majority of patients were male 56.2%. Patients' characteristics are presented in [Table 1].
Table 1: Patients' demographic characteristics


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The result indicates 95.8% and 92.2% know the indication and dosage of warfarin, respectively. However, over 50% do not know the consequence of missing a dose. In addition, only 42.2% of the patients know the frequency of INR monitoring. Furthermore, more than 50% of participants possess knowledge of warfarin interactions. There were 64.1% who know when to seek immediate medical attention [Table 2].
Table 2: Patients' knowledge on warfarin therapy according to domain


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Most participants (41.4%) possess a good knowledge of anticoagulation therapy. However, only 33.6% of patients have excellent knowledge while 1.6% of patients were found to have poor knowledge of warfarin therapy [Table 3].
Table 3: Patients' knowledge level of warfarin therapy


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  Discussion Top


Generally, knowledge of warfarin therapy among patients in this study was not satisfying. Only 33.6% of patients had excellent knowledge about warfarin therapy. This is consistent with findings from the previous studies where majority of patients had poor knowledge. [1],[2],[3],[11]

Low level of patients' knowledge may be attributed to inability to understand and retain the information provided during counseling. [12] This shows that pharmacists who provide patient education need to reinforce the information by using verbal repetition, picture, or written materials. Another possible reason for low patient knowledge might be inability to recall information during interview session. Some patients leave their treatment in the hands of caregivers and thus do not pay attention to the information provided by the pharmacists. [13]

Result shows less than 50% of participants know the consequence of missing dose, drug-warfarin interactions, and frequency of monitoring INR. These findings are consistent with other studies where participants had limited knowledge in similar areas of warfarin therapy. [1],[3] Emphasis should be placed on these areas during counseling sessions. To avoid unintentional skipping of these important items, there is a need to highlight them on the counseling checklist.

Patient education about the risk and benefits of anticoagulation is important. It is crucial to ensure that patients understand interactions and the importance of compliance and regular monitoring. [14] It is the pharmacist responsibility to ensure all patients receive relevant information regarding warfarin therapy. Pharmacists also need to assess patient's knowledge, identify areas of deficit, and educate the patient during each follow-up to improve patients' knowledge of therapy.


  Conclusion Top


Most patients attending Warfarin Clinic have insufficient knowledge about their therapy. In addition, this study has highlighted areas where improvement is needed. More investment in patient education is needed.

Acknowledgment

We wish to thank the Director General of Health, Malaysia, for permission to publish this paper.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Tang EO, Lai CS, Lee KK, Wong RS, Cheng G, Chan TY. Relationship between patients′ warfarin knowledge and anticoagulation control. Ann Pharmacother 2003;37:34-9.  Back to cited text no. 1
    
2.
Nadar S, Begum N, Kaur B, Sandhu S, Lip GY. Patients′ understanding of anticoagulant therapy in a multiethnic population. J R Soc Med 2003;96:175-9.  Back to cited text no. 2
    
3.
Yahaya AH, Hassali MA, Awaisu A, Shafie AA. Factors associated with Warfarin therapy knowledge and anticoagulation control among patients attending a Warfarin clinic in Malaysia. J Clin Diagn Res 2009;3:1663-70.  Back to cited text no. 3
    
4.
Hirsh J, Fuster V, Ansell J, Halperin JL; American Heart Association/American College of Cardiology Foundation. American Heart Association/American College of Cardiology Foundation guide to warfarin therapy. J Am Coll Cardiol 2003;41:1633-52.  Back to cited text no. 4
    
5.
Briggs AL, Jackson TR, Bruce S, Shapiro NL. The development and performance validation of a tool to assess patient anticoagulation knowledge. Res Social Adm Pharm 2005;1:40-59.  Back to cited text no. 5
    
6.
Barcellona D, Contu P, Marongiu F. Patient education and oral anticoagulant therapy. Haematologica 2002;87:1081-6.  Back to cited text no. 6
    
7.
Fang MC, Machtinger EL, Wang F, Schillinger D. Health literacy and anticoagulation-related outcomes among patients taking warfarin. J Gen Intern Med 2006;21:841-6.  Back to cited text no. 7
    
8.
Kagansky N, Knobler H, Rimon E, Ozer Z, Levy S. Safety of anticoagulation therapy in well-informed older patients. Arch Intern Med 2004;164:2044-50.  Back to cited text no. 8
    
9.
Naing NN. A practicle guide on determination of sample size in health science research. Malaysia: Pustaka Aman Press; 2010.  Back to cited text no. 9
    
10.
Zeolla MM, Brodeur MR, Dominelli A, Haines ST, Allie ND. Development and validation of an instrument to determine patient knowledge: The oral anticoagulation knowledge test. Ann Pharmacother 2006;40:633-8.  Back to cited text no. 10
    
11.
Davis NJ, Billett HH, Cohen HW, Arnsten JH. Impact of adherence, knowledge, and quality of life on anticoagulation control. Ann Pharmacother 2005;39:632-6.  Back to cited text no. 11
    
12.
Roddie AM, Pollock A. Therapeutic control of anticoagulation: How important is patient education? Clin Lab Haematol 1988;10:109-12.  Back to cited text no. 12
    
13.
Aslam M, Davis SS, Fletcher R. Compliance in medication by Asian immigrants. Nurs Times 1979;75:931-2.  Back to cited text no. 13
    
14.
Chiquette E, Amato MG, Bussey HI. Comparison of an anticoagulation clinic with usual medical care: Anticoagulation control, patient outcomes, and health care costs. Arch Intern Med 1998;158:1641-7.  Back to cited text no. 14
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3]



 

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